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Hpv and cancer. De-escalation strategies in the oncological management of HPV-positive oropharyngeal cancer.

HPV \u0026 Cancer: How the Base of the Tongue and Tonsils Are Affected

De-escalation strategies in the oncological management of HPV-positive oropharyngeal cancer. Source: ORL. Author s : Zahu, Renata; Sturzu, Daniela; Kacso, Gabriel; Ciuleanu, Elisabeta Abstract: HPV-positive oropharyngeal cancers hpv and cancer registered a rising incidence in the last two decades, especially among young nonsmoking adults.

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Retrospective studies have shown that the prognosis of these cancers is superior to the one of HPV-negative cancers. The combined treatment, such as radiochemotherapy or surgery followed by adjuvant radiotherapy, causes serious acute and late toxicities, like mucositis, dysphagia, xerostomia or cervical fibrosis. Given the young age group and the better prognosis of HPV-positive cancers, a series of new strategies to deintensify the treatment have been introduced, such as lower total dose of radiotherapy, omitting chemotherapy or replacing some cytotoxic agents with other less toxic agents.

The present paper presents the standard treatment for HPV-positive cancers and a review of the published or still pending studies for de-escalation.

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We also list some common late toxicities with an impact on the quality of life. Copyright of ORL. However, users may print, download, or email articles for individual use. This abstract may be abridged.

Colonhelp silhouette răspândirii mari a HPV-ului se consideră că și un singur contact sexual în viață poate fi suficient pentru a contracta un virus oncogen și din acest motiv orice femeie care a avut vreodată un contact sexual trebuie testată. Virusul poate persista în organism mulți ani, fără să existe semne. Conduita preventivă este foarte importantă și cunoașterea testelor, a etapelor hpv and cancer screening și vizitele periodice la medicul ginecolog, pot salva vieți. Human Papilloma Virus HPV : peste de genotipuri descoperite Papillomavirusul face parte din familia Papillomaviridae și este un virus care infectează atât omul, cât şi animalele. Human Papilloma Virus HPV este cel mai cunoscut virus Papilloma uman, un virus ADN cu diametrul de nm, uşor transmisibil prin contact direct piele pe pieleprin contact sexual și, uneori, de la mamă la făt.

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